Would you like to have a post-translational modification analysis performed?
analysis of post-translational modifications (PTMs) play a key role in understanding biological processes and evaluating protein quality in a variety of industrial and research contexts. PTMs can influence protein stability, activity, and localization, thereby affecting their functionality in biological systems.
What are post-translational modifications?
Post-translational modifications are chemical modifications that occur in proteins after their synthesis. These modifications include phosphorylation, glycosylation, methylation, and acetylation, among others. They are essential for regulating protein activity and modulating interactions with other molecules. These changes can significantly affect protein stability, cellular localization, and interactions with other biomolecules.
Applicable standards for post-translational modifications
Several standards govern analytical and production processes involving post-translational modifications. Regulations vary from one country to another, but generally address the validation of analytical methods and compliance with Good Manufacturing Practices (GMP) and Good Laboratory Practices (GLP). These standards ensure the authenticity and reproducibility of the results obtained, which is essential for applications in biotechnology and pharmaceutical development.
FILAB laboratory supports you with post-translational modification analysis
FILAB laboratory offers specialized solutions for post-translational modification analysis, combining expertise, state-of-the-art equipment, and a personalized approach.
Why choose FILAB for post-translational modification analysis?
FILAB stands out for its extensive experience in proteomics and PTM analysis. The laboratory provides reliable analysis supported by a team of experts in biochemistry and biotechnology. FILAB is committed to delivering high-quality results in compliance with applicable standards and regulations.
Our technical resources for post-translational modification analysis
FILAB is equipped with advanced technologies such as mass spectrometry, high-performance liquid chromatography (HPLC), and dedicated data analysis software. These tools enable the precise and detailed characterization of post-translational modifications in proteins.
Our post-translational modification analysis services
FILAB offers a range of services including PTM detection, quantification, and characterization. These services cover the analysis of proteins from various samples, such as biological fluids and cell cultures.
- Identify the identity and structure of biomolecules (peptide mapping, intact mass, disulfide bridges, circular dichroism, thermal stability, glycosylation, carbohydrates, and monosaccharides)
- Assess product purity and heterogeneity
- Identify and quantify glycosylation
- Detect and quantify HCP (Host Cell Proteins), residual DNA, and elemental impurities (ICH Q3D and USP 233)
- Extractables & leachables
- Measure physicochemical properties
Our additional services
FILAB also provides additional services that complement PTM analysis, including scientific consulting, data interpretation, and support in developing customized analytical methods.
Frequently asked questions
What are the main post-translational modifications to analyze?
How do post-translational modifications influence protein function?
What types of samples can be analyzed for post-translational modifications?
Why is mass spectrometry used to analyze PTMs?
Why perform an analysis of post-translational modifications?
